![]() ![]() All data were collected after induction of general anesthesia and trachéal intubation (with mechanical ventilation) and prior to opening the chest cavity. Confounding effects of cardiopulmonary bypass duration and variation in hemodynamics were controlled for. CABG patients had minimal mitral régurgitation and MVR patients had moderate to severe MVR. Patient selection criteria included EF > 45% and absence of significant pulmonary disease. METHODS: A prospective cohort study was approved by the IRB and to date data was collected on seven patients (4 CABG. This study compares changes in shunting (Qs/Qt) and deadspace ventilation (Vd/Vt) between mitral valve replacements (MVR) vs CABG. BACKGROUND: Respiratory dysfunction due to uneven distribution of ventilation to perfusion1 and increased shunting of venous blood through the lungs2 is a major cause of morbidity following cardiopulmonary bypass (CPB). ![]()
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